Cancer Stem Cells Philosophy and Therapies

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  • Engels
  • Hardcover
  • 9780674088740
  • 06 juni 2016
  • 272 pagina's
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A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.



An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

Rather than treat cancer by aggressively trying to eliminate all cancerous cells—with harmful side effects for patients—CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells—the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation.

To date, researchers have not agreed on the defining feature of CSCs—their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell’s relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

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Taal
en
Bindwijze
Hardcover
Oorspronkelijke releasedatum
06 juni 2016
Aantal pagina's
272
Illustraties
Met illustraties

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Hoofdauteur
Lucie Laplane
Hoofduitgeverij
Harvard University Press

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Editie
1
Extra groot lettertype
Nee
Product breedte
156 mm
Product hoogte
24 mm
Product lengte
235 mm
Studieboek
Nee
Verpakking breedte
155 mm
Verpakking hoogte
25 mm
Verpakking lengte
239 mm
Verpakkingsgewicht
771 g

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9780674088740
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